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4-Alkyl(aryl )-3-(N-p-tolylcarbamido)-6-bromo-3,4-dihydrocoumarins (2) have been prepared by action of Grignard reagents on 3 (N-p-tolyl-carba-mido)-6-bromocoumarin (1). 4, a-substituted acetic acid derivatives (3, 4 and 5) have been prepa red by Mi chae 1 condensa t i on of (1) wi th d i ethy1 malonate and ketones in presence of sodium ethoxide. But Michael condensation of (1) with diethyl malonate, ethyl acetoacetate or with ketones in presence of amines at 170-180° gave benzopyrano (3,4-c)-pyridine tri(or di)-ones (7,8,9,10 and 11). (1) reacted wi th acetyl acetone in presence of amines at the boiling point of the mixture or at room temperature to give 3,4,5,6-tetrahydro-1,3 benzoxazocines (12). The structures assigned are supported by elemental analysis and spectral data.read more
N El JADY ,R M SALEH ,G H SAYED ,H M MOSA ,
- 01 Aug 2011
- Volume Detail: VOLUME 8, NO2, JUN 1986
- Pages: 91
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2-(3-Aryl-2-pyrazoline-5-yl)-4H-benzoxazin-4-ones I react easily with amines in ethanol or glacial acetic acid to furnish the corresponding anilide or quinazolone derivatives. Acetylation, benzoylation and nitrosation of led to the formation of N-acetyl, N-benzoyl and N-nitroso derivatives. Other transformations of I were also investigated.read more
M A I SALEM ,E A SOLIMAN ,M A HASSAN ,I S SHERIF ,
- 01 Aug 2011
- Volume Detail: VOLUME 8, NO2, JUN 1986
- Pages: 97
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The pulse radiolysis of deaerated hydroquinone, (H2Q), solutions has been investigated. It has been shown that OH adds to H2Q to form the trihydroxycyc 1 ohexadi enyl radi ca 1 (H2Q-OH) to H2Q to form the tri hydroxycyc 1 0hexadienyl radical (H2Q-OH) with k = 5.25 x 109 M-1 5-1. This radical decays by first order kinetics giving the semiquinone radical (HQ). This reaction is catalysed by H . The spectrum of HQ. and its extinction coefficient were obtained. The decay of HQ is second order and k = 1.2 x 109 M-1 5-1. It is concluded that HQ disappears mainly through reaction with H2Q-H.read more
G HUGHES ,A A AL SUHYBANI ,
- 01 Aug 2011
- Volume Detail: VOLUME 8, NO2, JUN 1986
- Pages: 107
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"The reaction of 1-(4-anilino) morpholine/piperidine (I) with carbon disulfide, chloroacetic acid and hydrazine hydrate in ethanol yielded 4-(N-morpholino/piperidino)- phenylthiosemicarbazide (II) which on condensation with carbonyl compounds such as benzaldehyde, isatin, N-methylisatin furnished (VI),(VII) and (VIII) respectively. Treatment of (II) with sodium nitrite and hydrochloric acid afforded 5- 4-(N-morpholino) -anilino- 1,2,3,4 thiatriazole (IX). (I Jon condensation with ethyl chloroacetate followed by reaction with hydrazine hydrate afforded (III) which when treated with isatin, and N-methyl isatin, yielded (IV) & (V) respectively. 2-Methyl-3(4-N-morpholino/piperidino)phenyl-4-quinazolinones (X) and 2-styryl-3-[4-NmorpholiinolpiperledinolJ Phenyl-4- quinazolinones (XI) were also designed using 1."read more
R PRAKASH ,C R PARSAD ,R S VERMA ,
- 01 Aug 2011
- Volume Detail: VOLUME 8, NO2, JUN 1986
- Pages: 117
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The conductance of N-N -Di phenyl-S-A 1 kyl i sothi ouroni um bromi des is measured in methanol-water mixtures covering 32.63 < D <66.36 at 25°C. The data are ana lysed using the Fuoss-Onsager equation on a PDP 11/70 computer to get A , KA, and aO. A n shows dependence on the solvent composition.The ion-size parameter, aO, decreases with decrease in dielectric constant up to D = 57.14 and increase thereafter. Log KA vs. liD is not linear,indicating that solvent separated-ion pairs are found in systems characterized by strong hydrogen bonding. read more
F M A EL HALIM ,M A MAHMOUD ,A A HASNEIN ,N H EL HAMMY ,
- 01 Aug 2011
- Volume Detail: VOLUME 8, NO2, JUN 1986
- Pages: 125
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D-Glucitol is converted to 1,3:2,4-di-Q-ethylidene derivative and then into its 6-Q-tosyl es ter. Nuc 1 eophil i c di sp 1 acement with potass i urn thi oaceta te yi e 1 ds the 6-~-acetyl compound wh i ch may be saponifi ed to the thiol and oxidized to the blocked disulfide. Acid removal of the ethylidene group produces bis(6-deoxy-Q-glucitol) 6,6'-disulfide (11).Alternatively, reaction of 1,3:2,4-dio-Q-ethylidene-6-Q-tosyl-Q-glucitol, with 1,3:2,4-di-Q-ethylidene-6-~-acetyl-6-thio-Q-glucitol under basic conditions produces the monosulfide (12) which on deblocking by acid yields bis (6-deoxy-Q-glucitol )6,6'-sulfide (13). read more
A U REHMAN ,R L WHISTLER ,J R DANEIL ,
- 01 Aug 2011
- Volume Detail: VOLUME 8, NO2, JUN 1986
- Pages: 141
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Ab inito SCF-MO calculations of the interaction energies; changes in electronic charges distributions and dipole moments using the 4-31G and 6-31G basis sets are given for methyl fluoride dimer and cyclic trimer. A considerable deviation from addivity in hydrogen bond energies has been found. The importance of this non-pair additivity has been discussed.read more
A A HASNEIN ,
- 01 Aug 2011
- Volume Detail: VOLUME 8, NO2, JUN 1986
- Pages: 149
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The title compound (8) which is an intermediate towards the isochroman system, possibly related to the fungal metabolites of rotiorin type has been synthesised. Reaction of 3,5-dibenzyloxy-4-methylphenylacetyl chloride (I) with isobutyl magnesium bromide furnished 1-{3,5-dibenzyloxy-4methyl phenyl )-4-methylpentan-2-one (2) which was debenzylated to 1-{3,5dihydroxy-4-methylphenyl)-4-methylpentan-2-one (3). Formylation of the ketone (3) gave benzopyrillium salt (6) which was decomposed to 1-{2-formyl-3,5di hydroxy-4-methyl phenyl )-4-methylpentan-2-one (7) and on methylation gave 1-{2-formyl-3,5-dimethoxy-4-methylphenyl)-4-methylpentan-2-one (8). {~)-I(3,5-Diacetoxy-4-methylphenyl)-4-methylpentan-2-ylacetate (5) was obtained from (~)-I-{3,5-dihydroxy-4-methylphenyl )-4-methylpentan-2-ol (4) which was synthesised from the ketone (3).read more
E S TURNER ,N H RAMA ,
- 01 Aug 2011
- Volume Detail: VOLUME 8, NO2, JUN 1986
- Pages: 155
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The X-ray structure of the stable aroyl nitroxide (la) is consistent with significant electron delocalisation through the -CO.N(O·)-unit; deloca1 isation is less important in the aminocarbonyl nitroxide (2a).read more
T C JENKINS ,T J KING ,M J PERKINS ,S A HUSSIAN ,
- 01 Aug 2011
- Volume Detail: VOLUME 8, NO2, JUN 1986
- Pages: 159
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A method has been developed for ana lys is of wood sugars in samples from the pulp and paper industry. This high performance liquid chromatography (HPLC) method makes it possible to separate sugars using isocratic elution with water/methanol/ethyl formate. The separation of free glucose, mannose, galactose, arabinose and xylose present in quite unequal proportions in black liquor has been achieved. read more
S C PURI ,S M ANAND ,
- 01 Aug 2011
- Volume Detail: VOLUME 8, NO2, JUN 1986
- Pages: 163
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